Illini keep momentum goingISTANBUL Türkiye, the Arab world, most European countries as well as international rights groups have welcomed the International Criminal Court (ICC)'s arrest warrants for Israeli Prime Minister Benjamin Netanyahu and former Defense Minister Yoav Gallant. The ICC accused Netanyahu and Gallant of committing war crimes and crimes against humanity in the Gaza Strip. The court said there are "reasonable grounds" to believe the two bear criminal responsibility for "the war crime of starvation as a method of warfare; and the crimes against humanity of murder, persecution, and other inhumane acts." Israel has killed more than 44,000 Palestinians, most of them women and children since the Oct. 7, 2023 Hamas attacks, and caused widespread destruction and conditions of famine across the enclave. Türkiye hailed the arrest warrants, with President Recep Tayyip Erdogan calling the move a "courageous step." Foreign Minister Hakan Fidan described the warrants a good step towards “the realization of justice.” The Rome Statute, the treaty that established the ICC, includes 124 state parties that are legally bound to enforce its arrest warrants. 'Not political' In Europe, the responses by leaders varied in tone and approach to implementation. Josep Borrell, the bloc's foreign policy chief, underscored the importance of adhering to the ICC's decisions, saying the warrants are not politically motivated and should be respected and implemented. He said the warrants are "judicial, not political" and have nothing to do with anti-Semitism, as Netanyahu had described them. "Its decisions are legally binding: there is no pick & choose," he added. Spain's Second Vice-President Yolando Diaz welcomed the ICC decision, saying Madrid sides with justice. "Always on the side of justice and international law," Diaz said on X, adding: "The genocide of the Palestinian people cannot go unpunished." A spokesperson for British Prime Minister Keir Starmer also expressed respect for the ICC's independence without confirming whether the UK would uphold the warrants. A spokesperson for Keir Starmer, however, was quoted as saying that "the UK will always comply with its legal obligations as set out by domestic law and indeed international law." France also vowed to apply international law in this regard, as did Ireland, Sweden, Switzerland, Italy and the Netherlands, among others. Some nations, such as Austria, however, criticized the ICC's decision. Hungary's Prime Minister Viktor Orban said he would invite Netanyahu, while Germany said it would continue to back Israel. Arab world Arab countries also welcomed the court's arrest warrants. The Iraqi government “values the courageous and just stance taken by the International Criminal Court in issuing arrest warrants against the head of the Zionist entity's government and its former defense minister,” government spokesperson Basim al-Awadi said in a statement. Jordan voiced support for the court's decision, with Foreign Minister Ayman Safadi saying the verdict “must be respected and implemented without selectivity.” Algeria described the warrants "an important step and a tangible advancement toward ending decades of impunity and the evasion of accountability and punishment by the Israeli occupation.” Rights groups “The ICC arrest warrants against senior Israeli leaders and a Hamas official break through the perception that certain individuals are beyond the reach of the law," the Human Rights Watch (HRW) said in a statement. "These warrants should finally push the international community to address atrocities and secure justice for all victims in Palestine and Israel," it added. Stressing that Netanyahu has become a "wanted man," Amnesty International's Secretary General Agnes Callamard said: "ICC member states and the whole international community must stop at nothing until these individuals are brought to trial before the ICC’s independent and impartial judges." "There can be no ‘safe haven’ for those alleged to have committed war crimes and crimes against humanity," Callamard added.
A Kelowna group with concerns over a holiday sign in the downtown core has apparently got their wish. Each year, the Knights of Columbus put up a nativity scene display as part of the downtown Christmas decorations. The Knights go through a permitting process to do this, according to the City of Kelowna. This year, a sign saying "Keep Christ in Christmas" was part of the display, upsetting some people in the community, including the Kelowna Atheists, Skeptics, and Humanists Association (KASHA). However, the sign has since been removed. According to the city, the sign wasn't part of the permit. It was taken down on Tuesday, Dec. 10. On Monday, Dec. 9, (KASHA) expressed in a letter that it understands the nativity scene is part of Christmas symbols like "lights, festive trees, and other decorative displays." But KASHA had concerns with the "Keep Christ in Christmas" sign. "This message is not merely festive—it is political, advocating for a specific religious interpretation of the holiday," said KASHA in its letter to Black Press Media. "It may appear inoffensive and inconsequential for the city to endorse one religion so overtly. But it is important to understand that this does impact people of other faiths, and people who have no religious beliefs. It makes them feel less Canadian." Capital News has reached out to Knights of Columbus for comment.
Manchester City boss Pep Guardiola says his players are hurting over their unprecedented five-match losing streak but he trusts them to turn the situation around. The 4-0 home loss to Tottenham was a shattering blow just days after Guardiola signed a new two-year contract at the club. It was City's heaviest home defeat since 2003 and the first time they have lost five games in a row since 2006, before Sheikh Mansour began his trophy-ladened time as owner. Guardiola has never previously lost five successive games in his entire managerial career. It also leaves City eight points behind Premier League leaders Liverpool, following the Reds' 3-2 win at Southampton on Sunday. "I trust these players more than ever," said Guardiola. "I've never seen a player in my life who wants to perform badly or make a bad performance to the fans or for the club. Nobody wants it. "When they are in front of 60,000 people they want to perform well. But for many reasons, it hurts." Guardiola has vowed to find a solution to City's problems but with a crucial trip to Liverpool next weekend following Tuesday's Champions League encounter with Dutch side Feyenoord, it is not clear how he will achieve it. The twin absences of Ballon d'Or winner Rodri and Croatia midfielder Mateo Kovacic mean City's injury-hit defence has been exposed to too many attacks. On Saturday, Tottenham arrived with a gameplan to get the ball wide to Son Heung-min and Dejan Kulusevski as quickly as possible in an effort to isolate City's full-backs and put the central positions under strain. Kulusevski said he was looking forward to the challenge more than any other game this season and the outcome represented "the best result ever in my career". For City, the experience was more depressing. "At the moment we are not solid enough, that is the truth," added Guardiola. "I will not say a word that my time is not good but I have been there as a football player. They are not, 'hey it doesn't matter'. You want to do well but you have doubts." Consolation for Guardiola comes from the belief his side are playing well for extended periods within games. Against Tottenham, he felt the outcome would have been vastly different had Erling Haaland taken one of the two early chances that came his way. He will also hope John Stones, who was limited to 45 minutes at the weekend, will be in better shape for the Liverpool trip and both Manuel Akanji and Nathan Ake are fitter to allow some options in central defence, which in turn will give Kyle Walker and Josko Gvardiol more confidence after personally disappointing displays against Spurs. It is fair to assume someone as relentless and driven as Guardiola will not be paying lip service to his overall assessment of the situation. "When we started to lose, I said to people, 'we have to find a way'," he said. "That is my duty. "Sometimes you don't have it for many reasons, so which players at our disposal are better than the other ones? Lets' go to try and do it with them."ATLANTA (AP) — As she checked into a recent flight to Mexico for vacation, Teja Smith chuckled at the idea of joining another Women’s March on Washington . As a Black woman, she just couldn’t see herself helping to replicate the largest act of resistance against then-President Donald Trump’s first term in January 2017. Even in an election this year where Trump questioned his opponent’s race , held rallies featuring racist insults and falsely claimed Black migrants in Ohio were eating residents’ pets , he didn't just win a second term. He became the first Republican in two decades to clinch the popular vote, although by a small margin. “It’s like the people have spoken and this is what America looks like,” said Smith, the Los Angeles-based founder of the advocacy social media agency, Get Social. “And there’s not too much more fighting that you’re going to be able to do without losing your own sanity.” After Trump was declared the winner over Democratic Vice President Kamala Harris , many politically engaged Black women said they were so dismayed by the outcome that they were reassessing — but not completely abandoning — their enthusiasm for electoral politics and movement organizing. Black women often carry much of the work of getting out the vote in their communities. They had vigorously supported the historic candidacy of Harris, who would have been the first woman of Black and South Asian descent to win the presidency. Harris' loss spurred a wave of Black women across social media resolving to prioritize themselves, before giving so much to a country that over and over has shown its indifference to their concerns. AP VoteCast , a survey of more than 120,000 voters, found that 6 in 10 Black women said the future of democracy in the United States was the single most important factor for their vote this year, a higher share than for other demographic groups. But now, with Trump set to return to office in two months, some Black women are renewing calls to emphasize rest, focus on mental health and become more selective about what fight they lend their organizing power to. “America is going to have to save herself,” said LaTosha Brown, the co-founder of the national voting rights group Black Voters Matter. She compared Black women’s presence in social justice movements as “core strategists and core organizers” to the North Star, known as the most consistent and dependable star in the galaxy because of its seemingly fixed position in the sky. People can rely on Black women to lead change, Brown said, but the next four years will look different. “That’s not a herculean task that’s for us. We don’t want that title. ... I have no goals to be a martyr for a nation that cares nothing about me,” she said. AP VoteCast paints a clear picture of Black women's concerns. Black female voters were most likely to say that democracy was the single most important factor for their vote, compared to other motivators such as high prices or abortion. More than 7 in 10 Black female voters said they were “very concerned” that electing Trump would lead the nation toward authoritarianism, while only about 2 in 10 said this about Harris. About 9 in 10 Black female voters supported Harris in 2024, according to AP VoteCast, similar to the share that backed Democrat Joe Biden in 2020. Trump received support from more than half of white voters, who made up the vast majority of his coalition in both years. Like voters overall, Black women were most likely to say the economy and jobs were the most important issues facing the country, with about one-third saying that. But they were more likely than many other groups to say that abortion and racism were the top issues, and much less likely than other groups to say immigration was the top issue. Despite those concerns, which were well-voiced by Black women throughout the campaign, increased support from young men of color and white women helped expand Trump’s lead and secured his victory. Politically engaged Black women said they don’t plan to continue positioning themselves in the vertebrae of the “backbone” of America’s democracy. The growing movement prompting Black women to withdraw is a shift from history, where they are often present and at the forefront of political and social change. One of the earliest examples is the women’s suffrage movement that led to ratification in 1920 of the 19th Amendment to the Constitution , which gave women the right to vote. Black women, however, were prevented from voting for decades afterward because of Jim Crow-era literacy tests, poll taxes and laws that blocked the grandchildren of slaves from voting. Most Black women couldn’t vote until the Voting Rights Act of 1965. Black women were among the organizers and counted among the marchers brutalized on the Edmund Pettus Bridge in Alabama, during the historic march in 1965 from Selma to Montgomery that preceded federal legislation. Decades later, Black women were prominent organizers of the Black Lives Matter movement in response to the deaths of Black Americans at the hands of police and vigilantes. In his 2024 campaign, Trump called for leveraging federal money to eliminate diversity, equity and inclusion programs in government programs and discussions of race, gender or sexual orientation in schools. His rhetoric on immigration, including false claims that Black Haitian immigrants in Springfield, Ohio, were eating cats and dogs, drove support for his plan to deport millions of people . Tenita Taylor, a Black resident of Atlanta who supported Trump this year, said she was initially excited about Harris’ candidacy. But after thinking about how high her grocery bills have been, she feels that voting for Trump in hopes of finally getting lower prices was a form of self-prioritization. “People say, ‘Well, that’s selfish, it was gonna be better for the greater good,''' she said. “I’m a mother of five kids. ... The things that (Democrats) do either affect the rich or the poor.” Some of Trump’s plans affect people in Olivia Gordon’s immediate community, which is why she struggled to get behind the “Black women rest” wave. Gordon, a New York-based lawyer who supported the Party for Socialism and Liberation’s presidential nominee, Claudia de la Cruz, worries about who may be left behind if the 92% of Black women voters who backed Harris simply stopped advocating. “We’re talking millions of Black women here. If millions of Black women take a step back, it absolutely leaves holes, but for other Black women,” she said. “I think we sometimes are in the bubble of if it’s not in your immediate circle, maybe it doesn’t apply to you. And I truly implore people to understand that it does.” Nicole Lewis, an Alabama-based therapist who specializes in treating Black women’s stress, said she’s aware that Black women withdrawing from social impact movements could have a fallout. But she also hopes that it forces a reckoning for the nation to understand the consequences of not standing in solidarity with Black women. “It could impact things negatively because there isn’t that voice from the most empathetic group,” she said. “I also think it’s going to give other groups an opportunity to step up. ... My hope is that they do show up for themselves and everyone else.” Brown said a reckoning might be exactly what the country needs, but it’s a reckoning for everyone else. Black women, she said, did their job when they supported Harris in droves in hopes they could thwart the massive changes expected under Trump. “This ain’t our reckoning,” she said. “I don’t feel no guilt.” AP polling editor Amelia Thomson DeVeaux and Associated Press writer Linley Sanders in Washington contributed to this report. The Associated Press Health and Science Department receives support from the Robert Wood Johnson Foundation. The AP is solely responsible for all content.
WASHINGTON (Reuters) -U.S. President-elect Donald Trump said on Sunday the 2023 debt ceiling extension agreed by then House Speaker Kevin McCarthy and President Joe Biden will "go down as one of the dumbest political decisions made in years." Under the 2023 budget deal Congress suspended the debt ceiling until Jan. 1, 2025. The U.S. Treasury will be able to pay its bills for several months beyond that deadline, but Congress will have to address the issue, possibly around mid-year. In a post on Truth Social, Trump said, "The extension of the Debt Ceiling by a previous Speaker of the House, a good man and a friend of mine ... will go down as one of the dumbest political decisions made in years." He added, "The Democrats must be forced to take a vote on this treacherous issue NOW, during the Biden Administration, and not in June. They should be blamed for this potential disaster, not the Republicans!" Republicans, however, will control both chambers of Congress beginning on Jan. 3 and at least some of the party's lawmakers would have to go along with a debt limit increase or elimination in order for it to become law. Without the 2023 debt limit increase, the United States would have seen a historic default on its debt payments that would have roiled financial markets worldwide. A debt default would also likely have brought a downgrade in the U.S. credit rating, raising borrowing costs for businesses and individuals. At the time, several far-right Republicans in the House of Representatives had pushed for deeper federal spending cuts as a condition for raising the debt limit than what had been negotiated. About a week ago, with U.S. government discretionary funding due to expire on Dec. 20, Trump, encouraged by billionaire Elon Musk, demanded the debt limit either be eliminated or extended, possibly to 2029 when his presidency would end. That idea was tacked onto an extension of government funding into March, but it was quickly voted down by a coalition of House Democrats and hard-right Republicans, many of whom represent districts in Trump-leaning states. A government-funding bill without a debt-limit provision was then enacted into law. Next month, Republicans in the newly-elected Congress are expected to insist on deep federal spending cuts as a condition for raising the country's borrowing limit. Democrats earlier this month argued Trump's call for an immediate increase or elimination of the debt limit was motivated by his desire to make room for a new round of tax cuts that likely would lower revenues and thus add more to the debt. The national debt currently stands at about $36.1 trillion due to federal spending levels and tax cuts that have been enacted into law over several decades. (Reporting by Jasper Ward and Richard Cowan; Editing by Don Durfee and Chris Reese)
Liam Payne was remembered as a "son, brother and father" inside his funeral
Major heatwave to sweep millions this week
Donald Trump is returning to the world stage. So is his trollingBEMIDJI — The Region 2 Arts Council Board recently awarded $6,000 fellowships to sculptor Tim Nelsen and painter Donna Alena Hrabcakova. The Artist Fellowship award is intended for dedicated artists who have created a substantial independent body of work, have received recognition for their work and whose work has been selected for publication, solo exhibitions, commissions, presentations, readings or performances, a release said. Tim Nelsen has been a sculptor and metal artist since 2018 and uses exclusively recycled materials in his work. He is a graduate of Bemidji State University with a degree in Design Technology. Nelsen has won several People's Choice Awards for his works, including "Rumblefish" in 2016, "King Norway" in 2022 and 2023, and the Judge’s Award for the sculpture "Flying V" in 2023. Nelsen's works have been displayed in sculpture walks around the region, including the Bemidji Sculpture Walk, Sioux Falls Sculpture Walk, and in Mankato, Hutchinson and more throughout the Midwest. Nelsen has also served as an executive board member on the Bemidji Sculpture Walk since 2020. "I create art for one reason; it makes me happy," Nelsen said in the release. "The materials I use and the subjects I choose all speak to me on some level. From finding sculpting materials to sketching and creating the final product, the entire process is something I enjoy. I'm continually trying to improve as an artist by building my skill set and embracing new technologies that can help me work more efficiently." Painter Donna Alena Hrabcakova is originally from Giglovce, Slovakia, and has worked for 20 years as a Clinical Art Therapist at the Red Lake middle and high schools. She has shown work in several art shows, including the Bi-annual Exhibition at the Watermark Art Center, a Showing in Chicago on the Red Line Collection and other exhibits including the Jung Haus Gallery, Short North Art District and in Giglovce, Slovakia. One of her installations on Black Lives Matter is displayed in the Columbus, Ohio State House. Hrabcakova came to Red Lake from Ohio to serve as a National Trauma Therapist following a Red Lake school shooting tragedy in 2005. Her passion is working with adolescents to help them cope with intergenerational trauma, PTSD and other issues that arise from suffering and loss. Her passion and love play into her artwork's narrative of family, love, tragedy, war and healing. Hrabcakova uses acrylics, mixed media, materials that are recycled from nature and molding pastes. Hrabcakova's goal for her fellowship is to start a whole new collection with the juxtaposition of freedom, sovereignty, diaspora and the concept of community. She will use references from Red Lake Nation, the Ukrainian invasion of Russia and her family's stories of being sent to internment camps in Presov, Slovakia, and later Auschwitz. "All art shows start with a dream, a vision and a good story," Hrabcakova said in the release. "This (fellowship project) is based on a very personal story that reaches deep inside of my soul."Everyone on the Patriots had a bad day in Week 12 loss to Dolphins
VICTORIA — British Columbia Premier David Eby says Canada’s premiers and the federal government have hatched a game plan over possible U.S. tariffs, where Conservative premiers lobby their Republican counterparts and left-leaning leaders court the Democrats, while the federal government focuses on president-elect Donald Trump. Eby says the premiers and Prime Minister Justin Trudeau talked about using their political diversity and connections to approach politicians and business leaders in the United States, as talks over Trump’s proposed 25 per cent tariff on imports from Canada and Mexico ramp up. He says it has been discussed that Conservative premiers Danielle Smith in Alberta, Doug Ford in Ontario and Nova Scotia’s John Houston are well-placed to lobby their contacts with Republican governors and business leaders. In a year-end interview, Eby says as a New Democrat leader he will likely have more in common speaking with Democrat governors and business leaders from the West Coast states. He says Canada’s diversity of representation, ranging from the right and left sides of the political spectrum, can bring leverage and advantages in tariff talks. Eby also says — if it is deemed helpful — he is prepared to appear on American’s right-leaning Fox News TV network as did premiers Ford and Smith. This report by The Canadian Press was first published Dec. 5, 2024. Dirk Meissner, The Canadian Press
About 1 in 8 Canadians think Canada should become 51st American state: pollSingapore companies ‘slightly optimistic’ about next 6 months, after exiting sales contraction phase in Q3: surveyUS politicians on both sides have reacted to news that former US President Jimmy Carter, who as president brokered peace between Israel and Egypt and later received the Nobel Peace Prize for his humanitarian work, has died at age 100. or signup to continue reading Here are some of the immediate comments. PRESIDENT JOE BIDEN AND FIRST LADY JILL BIDEN "Today, America and the world lost an extraordinary leader, statesman and humanitarian. Over six decades, we had the honour of calling Jimmy Carter a dear friend. But, what's extraordinary about Jimmy Carter, though, is that millions of people throughout America and the world who never met him thought of him as a dear friend as well." US PRESIDENT-ELECT DONALD TRUMP "The challenges Jimmy faced as President came at a pivotal time for our country and he did everything in his power to improve the lives of all Americans. For that, we all owe him a debt of gratitude. Melania and I are thinking warmly of the Carter Family and their loved ones during this difficult time. We urge everyone to keep them in their hearts and prayers." FORMER US PRESIDENT BILL CLINTON AND FORMER SECRETARY OF STATE HILLARY CLINTON "From his commitment to civil rights as a state senator and governor of Georgia; to his efforts as President to protect our natural resources in the Arctic National Wildlife Refuge, make energy conservation a national priority, return the Panama Canal to Panama, and secure peace between Egypt and Israel at Camp David; to his post-Presidential efforts at the Carter Centre supporting honest elections, advancing peace, combating disease, and promoting democracy; to his and Rosalynn's devotion and hard work at Habitat for Humanity—he worked tirelessly for a better, fairer world." US SENATOR MITCH MCCONNELL "Elaine and I join the Senate and the nation in mourning the passing of our 39th president, Jimmy Carter." "President Carter served during times of tension and uncertainty, both at home and abroad. But his calm spirit and deep faith seemed unshakeable. Jimmy Carter served as our commander-in-chief for four years, but he served as the beloved, unassuming Sunday school teacher at Maranatha Baptist Church in Plains, Georgia for forty. And his humble devotion leaves us little doubt which of those two important roles he prized the most." US HOUSE SPEAKER MIKE JOHNSON "Today, the thoughts of Americans and the prayers of Congress are lifted up on behalf of the Carter family. President Carter's story was one of humble beginnings, and his life is a testament to the boundless opportunities available in this great nation. Because of his work in brokering the Camp David Accords and his advocacy with Habitat for Humanity, the world is a more peaceful place, and more Americans have a place to call home. No one can deny that President Carter led an extraordinary life of service to his country. May he rest in peace." US REPRESENTATIVE MIKE TURNER "I am deeply saddened to learn about the death of President Jimmy Carter. President Carter was a man of integrity who was guided by his faith. I join all Americans in saluting President Carter for his lifetime of service, first as a naval officer, then as a senator in the Georgia State Senate, then as Governor of Georgia, and, finally, as President of the United States. I would like to extend my heartfelt condolences to the Carter family." US SENATOR MARK WARNER "President Carter will be remembered by what he built and left behind for us – a model of service late into life, a tireless devotion to family and philanthropy, and a more peaceful world to call home." Advertisement Sign up for our newsletter to stay up to date. We care about the protection of your data. Read our . Advertisement
AP Business SummaryBrief at 2:22 p.m. EST
The value of global music copyright surged to $45.5 billion in 2023, marking an 11% increase from the previous year. This reflects the growing economic strength of music rights, which were valued at $25 billion in 2014. If current trends continue, music copyright could double in value over a decade. Record Labels And Streaming: Key Drivers Of Growth According to economist Will Page ‘s annual industry report ( via Billboard), record labels accounted for the largest share of the music copyright market, generating $28.5 billion in 2023—a 21% year-over-year increase. See Also: Apple Music Launched A $450 Limited-Edition Coffee Table Book: ‘100 Best Albums’ Streaming continued to dominate revenue sources, with a 10.4% growth rate. Physical music sales also performed strongly, as vinyl sales rose 15.4%, outpacing CDs in many regions. Page predicted vinyl could become a $3 billion industry by 2028, driven by higher unit prices and global demand. Major publicly traded record labels such as Universal Music Group NV UMGNF , Warner Music Group Corp WMG , and Sony Group Corp ‘s SONY Sony Music Entertainment were among the primary beneficiaries of these trends. UMG, for instance, reported $3.2 billion in Q3 2024 revenue, showing strong performance fueled by streaming and physical sales. Shifting Dynamics In Songwriter Royalties Moreover, collective management organizations (CMOs), which collect royalties on behalf of songwriters and publishers, saw revenues rise by 11% to $12.9 billion in 2023. Digital collections from CMOs have now surpassed those from broadcast and radio, reflecting the dominance of streaming platforms over traditional media. However, publishers are increasingly turning to direct licensing agreements, bypassing CMOs to avoid administrative delays and fees. "A song that spikes in mid-March, for example, takes 201 days to pay the artist and 383 days to pay the songwriter," Page explained. These delays can erode a third of songwriter revenue due to transaction costs. Music Surpasses Cinema The music industry's recovery following the pandemic has enabled it to overtake cinema in terms of economic output. In 2023, music was 38% larger than cinema, a stark contrast to 2019 when cinema led by 33%. Music copyright figures reflect trade revenue that benefits rights holders, while cinema's $33.2 billion box office revenues are divided between distribution and production. Companies like Live Nation Entertainment LYV , which operate in recorded music and live performance sectors, have capitalized on this momentum. Streaming’s Global Trade Advantage Streaming platforms have created new opportunities for artists from regions with lower royalty rates. North America and Europe, which account for 80% of streaming revenue growth, provide significantly higher payouts compared to Latin America and Asia. For example, Colombian artists like J. Balvin and Shakira earned nearly $100 million from U.S. streams in 2023, six times what they would have generated in their home country. Publicly traded streaming platforms such as Spotify Technology SA SPOT and Tencent Music Entertainment TME play a crucial role in this dynamic. Spotify benefits from premium subscription revenues in high-value markets, while Tencent Music caters to large audiences in Asia with a range of streaming and social entertainment services. Read Next: Spotify Stock Climbs Despite Q3 EPS Miss, Revenue Beat (CORRECTED) Cover image made using artificial intelligence via Dall-E. © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.(Azacitidine + cedazuridine) is under clinical development by Taiho Oncology and currently in Phase III for Myelodysplastic Syndrome. According to GlobalData, Phase III drugs for Myelodysplastic Syndrome have a 33% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. (Azacitidine + cedazuridine) overview ASTX-030, a fixed dose combination of azacitidine and cedazuridine is under development for the treatment of myelodysplastic syndromes (MDS), chronic myelocytic leukemia (CML), refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, chronic myelomonocytic leukemia (CMML), and acute myeloid leukemia (AML). It is administered by oral route. It acts by targeting DNA (cytosine 5) methyltransferase 1 and cytosine deaminase (CDA). The drug candidate is being developed based on Pyramid technology. Taiho Oncology overview Taiho Oncology, a subsidiary of Taiho Pharmaceutical Co Ltd, is a provider of cancer treatments and solutions. The company manufactures and markets cancer anti-metabolites as well as targeted small molecule inhibitors. Its products portfolio includes oral drugs for the treatment of gastric cancer, colorectal cancer and a variety of solid tumours. Taiho Oncology’s pipeline products includes anti metabolic agents and selectively targeted agents. The company’s LONSURF is an anti-cancer drug for the treatment of metastatic colorectal cancer. Taiho Oncology is headquartered in Princeton, New Jersey, the US. For a complete picture of (Azacitidine + cedazuridine)’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .
WASHINGTON (Reuters) -Jimmy Carter, the earnest Georgia peanut farmer who as U.S. president struggled with a bad economy and the Iran hostage crisis but brokered peace between Israel and Egypt and later received the Nobel Peace Prize for his humanitarian work, died at his home in Plains, Georgia, on Sunday, the Carter Center said. He was 100. “My father was a hero, not only to me but to everyone who believes in peace, human rights, and unselfish love,” said Chip Carter, the former president’s son. “My brothers, sister, and I shared him with the rest of the world through these common beliefs. The world is our family because of the way he brought people together, and we thank you for honoring his memory by continuing to live these shared beliefs.” The Carter Center said there will be public observances in Atlanta and Washington. These events will be followed by a private interment in Plains, it said. Final arrangements for the former president’s state funeral are still pending, according to the center. Jimmy Carter, a Democrat, served as president from January 1977 to January 1981 after defeating incumbent Republican President Gerald Ford in the 1976 U.S. election. Carter was swept from office four years later in an electoral landslide as voters embraced Republican challenger Ronald Reagan, the former actor and California governor. Carter lived longer after his term in office than any other U.S. president. Along the way, he earned a reputation as a better former president than he was a president – a status he readily acknowledged. His one-term presidency was marked by the highs of the 1978 Camp David accords between Israel and Egypt, bringing some stability to the Middle East. But it was dogged by an economy in recession, persistent unpopularity and the embarrassment of the Iran hostage crisis that consumed his final 444 days in office. In recent years, Carter had experienced several health issues including melanoma that spread to his liver and brain. Carter decided to receive hospice care in February 2023 instead of undergoing additional medical intervention. His wife, Rosalynn Carter, died on Nov. 19, 2023, at age 96. He looked frail when he attended her memorial service and funeral in a wheelchair. Carter left office profoundly unpopular but worked energetically for decades on humanitarian causes. He was awarded the Nobel Peace Prize in 2002 in recognition of his “untiring effort to find peaceful solutions to international conflicts, to advance democracy and human rights, and to promote economic and social development.” Carter had been a centrist as governor of Georgia with populist tendencies when he moved into the White House as the 39th U.S. president. He was a Washington outsider at a time when America was still reeling from the Watergate scandal that led Republican Richard Nixon to resign as president in 1974 and elevated Ford from vice president. “I’m Jimmy Carter and I’m running for president. I will never lie to you,” Carter promised with an ear-to-ear smile. Asked to assess his presidency, Carter said in a 1991 documentary: “The biggest failure we had was a political failure. I never was able to convince the American people that I was a forceful and strong leader.” Despite his difficulties in office, Carter had few rivals for accomplishments as a former president. He gained global acclaim as a tireless human rights advocate, a voice for the disenfranchised and a leader in the fight against hunger and poverty, winning the respect that eluded him in the White House. Carter won the Nobel Peace Prize in 2002 for his efforts to promote human rights and resolve conflicts around the world, from Ethiopia and Eritrea to Bosnia and Haiti. His Carter Center in Atlanta sent international election-monitoring delegations to polls around the world. A Southern Baptist Sunday school teacher since his teens, Carter brought a strong sense of morality to the presidency, speaking openly about his religious faith. He also sought to take some pomp out of an increasingly imperial presidency – walking, rather than riding in a limousine, in his 1977 inauguration parade. The Middle East was the focus of Carter’s foreign policy. The 1979 Egypt-Israel peace treaty, based on the 1978 Camp David accords, ended a state of war between the two neighbors. Carter brought Egyptian President Anwar Sadat and Israeli Prime Minister Menachem Begin to the Camp David presidential retreat in Maryland for talks. Later, as the accords seemed to be unraveling, Carter saved the day by flying to Cairo and Jerusalem for personal shuttle diplomacy. The treaty provided for Israeli withdrawal from Egypt’s Sinai Peninsula and establishment of diplomatic relations. Begin and Sadat each won a Nobel Peace Prize in 1978. By the 1980 election, the overriding issues were double-digit inflation, interest rates that exceeded 20% and soaring gas prices, as well as the Iran hostage crisis that brought humiliation to America. These issues marred Carter’s presidency and undermined his chances of winning a second term. HOSTAGE CRISIS On Nov. 4, 1979, revolutionaries devoted to Iran’s Ayatollah Ruhollah Khomeini had stormed the U.S. Embassy in Tehran, seized the Americans present and demanded the return of the ousted shah Mohammad Reza Pahlavi, who was backed by the United States and was being treated in a U.S. hospital. The American public initially rallied behind Carter. But his support faded in April 1980 when a commando raid failed to rescue the hostages, with eight U.S. soldiers killed in an aircraft accident in the Iranian desert. Carter’s final ignominy was that Iran held the 52 hostages until minutes after Reagan took his oath of office on Jan. 20, 1981, to replace Carter, then released the planes carrying them to freedom. In another crisis, Carter protested the former Soviet Union’s 1979 invasion of Afghanistan by boycotting the 1980 Olympics in Moscow. He also asked the U.S. Senate to defer consideration of a major nuclear arms accord with Moscow. Unswayed, the Soviets remained in Afghanistan for a decade. Carter won narrow Senate approval in 1978 of a treaty to transfer the Panama Canal to the control of Panama despite critics who argued the waterway was vital to American security. He also completed negotiations on full U.S. ties with China. Carter created two new U.S. Cabinet departments – education and energy. Amid high gas prices, he said America’s “energy crisis” was “the moral equivalent of war” and urged the country to embrace conservation. “Ours is the most wasteful nation on earth,” he told Americans in 1977. In 1979, Carter delivered what became known as his “malaise” speech to the nation, although he never used that word. “After listening to the American people I have been reminded again that all the legislation in the world can’t fix what’s wrong with America,” he said in his televised address. “The threat is nearly invisible in ordinary ways. It is a crisis of confidence. It is a crisis that strikes at the very heart and soul and spirit of our national will. The erosion of our confidence in the future is threatening to destroy the social and the political fabric of America.” As president, the strait-laced Carter was embarrassed by the behavior of his hard-drinking younger brother, Billy Carter, who had boasted: “I got a red neck, white socks, and Blue Ribbon beer.” ‘THERE YOU GO AGAIN’ Jimmy Carter withstood a challenge from Massachusetts Senator Edward Kennedy for the 1980 Democratic presidential nomination but was politically diminished heading into his general election battle against a vigorous Republican adversary. Reagan, the conservative who projected an image of strength, kept Carter off balance during their debates before the November 1980 election. Reagan dismissively told Carter, “There you go again,” when the Republican challenger felt the president had misrepresented Reagan’s views during one debate. Carter lost the 1980 election to Reagan, who won 44 of the 50 states and amassed an Electoral College landslide. James Earl Carter Jr. was born on Oct. 1, 1924, in Plains, Georgia, one of four children of a farmer and shopkeeper. He graduated from the U.S. Naval Academy in 1946, served in the nuclear submarine program and left to manage the family peanut farming business. He married his wife, Rosalynn, in 1946, a union he called “the most important thing in my life.” They had three sons and a daughter. Carter became a millionaire, a Georgia state legislator and Georgia’s governor from 1971 to 1975. He mounted an underdog bid for the 1976 Democratic presidential nomination, and out-hustled his rivals for the right to face Ford in the general election. With Walter Mondale as his vice presidential running mate, Carter was given a boost by a major Ford gaffe during one of their debates. Ford said that “there is no Soviet domination of Eastern Europe and there never will be under a Ford administration,” despite decades of just such domination. Carter edged Ford in the election, even though Ford actually won more states – 27 to Carter’s 23. Not all of Carter’s post-presidential work was appreciated. Former President George W. Bush and his father, former President George H.W. Bush, both Republicans, were said to have been displeased by Carter’s freelance diplomacy in Iraq and elsewhere. In 2004, Carter called the Iraq war launched in 2003 by the younger Bush one of the most “gross and damaging mistakes our nation ever made.” He called George W. Bush’s administration “the worst in history” and said Vice President Dick Cheney was “a disaster for our country.” In 2019, Carter questioned Republican Donald Trump’s legitimacy as president, saying “he was put into office because the Russians interfered on his behalf.” Trump responded by calling Carter “a terrible president.” Carter also made trips to communist North Korea. A 1994 visit defused a nuclear crisis, as President Kim Il Sung agreed to freeze his nuclear program in exchange for resumed dialogue with the United States. That led to a deal in which North Korea, in return for aid, promised not to restart its nuclear reactor or reprocess the plant’s spent fuel. But Carter irked Democratic President Bill Clinton’s administration by announcing the deal with North Korea’s leader without first checking with Washington. In 2010, Carter won the release of an American sentenced to eight years hard labor for illegally entering North Korea. Carter wrote more than two dozen books, ranging from a presidential memoir to a children’s book and poetry, as well as works about religious faith and diplomacy. His book “Faith: A Journey for All,” was published in 2018.
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