Xander_D/iStock via Getty Images Palo Alto Networks ( NASDAQ: PANW ) continues on a path towards platformization in the cybersecurity space to limited progress. The market continues to overly love the story with the stock already rebounding from the big selloff in February to reach new all-time If you'd like to learn more about how to best position yourself in under valued stocks mispriced by the market to end November, consider joining Out Fox The Street . The service offers a model portfolio, daily updates, trade alerts and real-time chat. Sign up now for a risk-free 2-week trial to started finding the best stocks with potential to double and triple in the next few years. Stone Fox Capital (aka Mark Holder) is a CPA with degrees in Accounting and Finance. He is also Series 65 licensed and has 30 years of investing experience, including 10 years as a portfolio manager. Out Fox The Street Learn more Analyst’s Disclosure: I/we have no stock, option or similar derivative position in any of the companies mentioned, and no plans to initiate any such positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article. The information contained herein is for informational purposes only. Nothing in this article should be taken as a solicitation to purchase or sell securities. Before buying or selling any stock, you should do your own research and reach your own conclusion or consult a financial advisor. Investing includes risks, including loss of principal. Seeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.
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Tiny, wireless antennas use light to monitor cellular communication December 20, 2024 Massachusetts Institute of Technology Researchers developed a biosensing technique that eliminates the need for wires. Instead, tiny, wireless antennas use light to detect minute electrical signals in the solution around them. Facebook Twitter Pinterest LinkedIN Email Monitoring electrical signals in biological systems helps scientists understand how cells communicate, which can aid in the diagnosis and treatment of conditions like arrhythmia and Alzheimer's. But devices that record electrical signals in cell cultures and other liquid environments often use wires to connect each electrode on the device to its respective amplifier. Because only so many wires can be connected to the device, this restricts the number of recording sites, limiting the information that can be collected from cells. MIT researchers have now developed a biosensing technique that eliminates the need for wires. Instead, tiny, wireless antennas use light to detect minute electrical signals. Small electrical changes in the surrounding liquid environment alter how the antennas scatter the light. Using an array of tiny antennas, each of which is one-hundredth the width of a human hair, the researchers could measure electrical signals exchanged between cells, with extreme spatial resolution. The devices, which are durable enough to continuously record signals for more than 10 hours, could help biologists understand how cells communicate in response to changes in their environment. In the long run, such scientific insights could pave the way for advancements in diagnosis, spur the development of targeted treatments, and enable more precision in the evaluation of new therapies. "Being able to record the electrical activity of cells with high throughput and high resolution remains a real problem. We need to try some innovative ideas and alternate approaches," says Benoît Desbiolles, a former postdoc in the MIT Media Lab and lead author of a paper on the devices. He is joined on the paper by Jad Hanna, a visiting student in the Media Lab; former visiting student Raphael Ausilio; former postdoc Marta J. I. Airaghi Leccardi; Yang Yu, a scientist at Raith America, Inc.; and senior author Deblina Sarkar, the AT&T Career Development Assistant Professor in the Media Lab and MIT Center for Neurobiological Engineering and head of the Nano-Cybernetic Biotrek Lab. The research appears today in Science Advances . "Bioelectricity is fundamental to the functioning of cells and different life processes. However, recording such electrical signals precisely has been challenging," says Sarkar. "The organic electro-scattering antennas (OCEANs) we developed enable recording of electrical signals wirelessly with micrometer spatial resolution from thousands of recording sites simultaneously. This can create unprecedented opportunities for understanding fundamental biology and altered signaling in diseased states as well as for screening the effect of different therapeutics to enable novel treatments." Biosensing with light The researchers set out to design a biosensing device that didn't need wires or amplifiers. Such a device would be easier to use for biologists who may not be familiar with electronic instruments. "We wondered if we could make a device that converts the electrical signals to light and then use an optical microscope, the kind that is available in every biology lab, to probe these signals," Desbiolles says. Initially, they used a special polymer called PEDOT:PSS to design nanoscale transducers that incorporated tiny pieces of gold filament. Gold nanoparticles were supposed to scatter the light -- a process that would be induced and modulated by the polymer. But the results weren't matching up with their theoretical model. The researchers tried removing the gold and, surprisingly, the results matched the model much more closely. "It turns out we weren't measuring signals from the gold, but from the polymer itself. This was a very surprising but exciting result. We built on that finding to develop organic electro-scattering antennas," he says. The organic electro-scattering antennas, or OCEANs, are composed of PEDOT:PSS. This polymer attracts or repulses positive ions from the surrounding liquid environment when there is electrical activity nearby. This modifies its chemical configuration and electronic structure, altering an optical property known as its refractive index, which changes how it scatters light. When researchers shine light onto the antenna, the intensity of the light it scatters back changes in proportion to the electrical signal present in the liquid. With thousands or even millions of tiny antennas in an array, each only 1 micrometer wide, the researchers can capture the scattered light with an optical microscope and measure electrical signals from cells with high resolution. Because each antenna is an independent sensor, the researchers do not need to pool the contribution of multiple antennas to monitor electrical signals, which is why OCEANs can detect signals with micrometer resolution. Intended for in vitrostudies, OCEAN arrays are designed to have cells cultured directly on top of them and put under an optical microscope for analysis. "Growing" antennas on a chip Key to the devices is the precision with which the researchers can fabricate arrays in the MIT.nano facilities. They start with a glass substrate and deposit layers of conductive then insulating material on top, each of which is optically transparent. Then they use a focused ion beam to cut hundreds of nanoscale holes into the top layers of the device. This special type of focused ion beam enables high-throughput nanofabrication. "This instrument is basically like a pen where you can etch anything with a 10-nanometer resolution," he says. They submerge the chip in a solution that contains the precursor building blocks for the polymer. By applying an electric current to the solution, that precursor material is attracted into the tiny holes on the chip, and mushroom-shaped antennas "grow" from the bottom up. The entire fabrication process is relatively fast, and the researchers could use this technique to make a chip with millions of antennas. "This technique could be easily adapted so it is fully scalable. The limiting factor is how many antennas we can image at the same time," he says. The researchers optimized the dimensions of the antennas and adjusted parameters, which enabled them to achieve high enough sensitivity to monitor signals with voltages as low as 2.5 millivolts in simulated experiments. Signals sent by neurons for communication are usually around 100 millivolts. "Because we took the time to really dig in and understand the theoretical model behind this process, we can maximize the sensitivity of the antennas," he says. OCEANs also responded to changing signals in only a few milliseconds, enabling them to record electrical signals with fast kinetics. Moving forward, the researchers want to test the devices with real cell cultures. They also want to reshape the antennas so they can penetrate cell membranes, enabling more precise signal detection. In addition, they want to study how OCEANs could be integrated into nanophotonic devices, which manipulate light at the nanoscale for next-generation sensors and optical devices. This research is funded, in part, by the U.S. National Institutes of Health and the Swiss National Science Foundation. Story Source: Materials provided by Massachusetts Institute of Technology . Original written by Adam Zewe. 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The Reserve Bank of India ’s gold purchases has helped the central bank to hold up foreign exchange reserves amidst a huge pullout by foreign portfolio investors that saw reserves contracting by $47 billion in five weeks. While the value of foreign currency assets dipped $1.1 billion on an incremental basis since the beginning of the fiscal 2024-25 upto November 15, value of gold in reserves rose $13 billion in the same period and help shore up overall foreign exchange reserves by $11 billion, the latest Reserve Bank of India data shows. Reserves including gold, foreign currency assets and SDR are now at $ 658 billion. The central bank added 44.76 tonnes to its stock of gold between March 29 and October 25 this year, ramping up gold stocks from 822.09 tonnes to 866.65 tonnes during the period according to the latest Reserve Bank of India data. Gold prices rose 23 percent during the period according to the World Gold Council, while RBI’s value of gold in reserves rose 31 percent. The gold body says the demand from central banks is triggering a price rally in gold, which in turn helps them with valuation gains. Central banks have started looking for safety of their assets amidst an uncertain geopolitical environment. “We are building up gold reserves, the data is released from time-to-time,” said RBI governor Shaktikanta Das at the post policy media conference on April 5. “All aspects while building up the reserves are assessed and then we make a decision.” Web Development JavaScript Essentials: Unlock AI-Driven Insights with ChatGPT By - Metla Sudha Sekhar, IT Specialist and Developer View Program Finance Crypto & NFT Mastery: From Basics to Advanced By - CA Raj K Agrawal, Chartered Accountant View Program Marketing Future of Marketing & Branding Masterclass By - Dr. David Aaker, Professor Emeritus at the Haas School of Business, UC Berkeley, Author | Speaker | Thought Leader | Branding Consultant View Program Office Productivity Mastering Microsoft Office: Word, Excel, PowerPoint, and 365 By - Metla Sudha Sekhar, IT Specialist and Developer View Program Marketing Marketing & Sales Strategies for Startups: From Concept to Conversion By - Dr. Anu Khanchandani, Startup Coach with more than 25 years of experience View Program Leadership Business Storytelling Masterclass By - Ameen Haque, Founder of Storywallahs View Program Artificial Intelligence(AI) Mastering C++ Fundamentals with Generative AI: A Hands-On By - Metla Sudha Sekhar, IT Specialist and Developer View Program Marketing Modern Marketing Masterclass by Seth Godin By - Seth Godin, Former dot com Business Executive and Best Selling Author View Program Office Productivity Microsoft Word Mastery: From Beginner to Expert By - CA Raj K Agrawal, Chartered Accountant View Program Finance A2Z Of Money By - elearnmarkets, Financial Education by StockEdge View Program Office Productivity Zero to Hero in Microsoft Excel: Complete Excel guide 2024 By - Metla Sudha Sekhar, IT Specialist and Developer View Program Finance Startup Fundraising: Essential Tactics for Securing Capital By - Dr. Anu Khanchandani, Startup Coach with more than 25 years of experience View Program Web Development Master RESTful APIs with Python and Django REST Framework: Web API Development By - Metla Sudha Sekhar, IT Specialist and Developer View Program Artificial Intelligence(AI) ChatGPT Mastery from Zero to Hero: The Complete AI Course By - Metla Sudha Sekhar, IT Specialist and Developer View Program Leadership Crafting a Powerful Startup Value Proposition By - Dr. Anu Khanchandani, Startup Coach with more than 25 years of experience View Program Finance Financial Literacy i.e Lets Crack the Billionaire Code By - CA Rahul Gupta, CA with 10+ years of experience and Accounting Educator View Program Office Productivity Advanced Excel Course - Financial Calculations & Excel Made Easy By - Anirudh Saraf, Founder- Saraf A & Associates, Chartered Accountant View Program Web Development Java 21 Essentials for Beginners: Build Strong Programming Foundations By - Metla Sudha Sekhar, IT Specialist and Developer View Program Artificial Intelligence(AI) Master in Python Language Quickly Using the ChatGPT Open AI By - Metla Sudha Sekhar, IT Specialist and Developer View Program Finance A2Z Of Finance: Finance Beginner Course By - elearnmarkets, Financial Education by StockEdge View Program The RBI has been actively accumulating gold as part of its reserves management strategy since December 2017. But it has become more aggressive post COVID and is one of the major buyers of gold among global central banks. The central bank’s stated objective of holding gold in reserves is mainly to diversify its foreign currency assets base, as a hedge against inflation and foreign currency risks. Central banks globally have actively started accumulating gold more aggressively after the Russia- Ukraine war started in February of 2022. The RBI too has followed the trend of central banks globally. Active gold purchases by central banks are expected to continue in 2025 market analysts said. “The market is likely to remain supported by official sector purchases continuing at historically elevated levels and resilient physical demand” said Joni Teves, Precious Metals Strategist, UBS Investment Bank in a research note. Goldman Sachs co-Head of Global Commodities Research Samantha Dart sees gold prices hitting $3,000 an ounce by the end of 2025. She said on Bloomberg TV on November 21. Nominations for ET MSME Awards are now open. The last day to apply is November 30, 2024. Click here to submit your entry for any one or more of the 22 categories and stand a chance to win a prestigious award. (You can now subscribe to our Economic Times WhatsApp channel )LONDON — Pooches in pullovers paraded past Buckingham Palace on Saturday for a gathering of dogs in Christmas sweaters to raise funds for rescue charities. People and dogs take part in the Rescue Dogs of London and Friends Christmas Jumper Parade on Saturday outside Buckingham Palace in central London. About 130 pets, and their owners, walked Saturday from St. James's Park and along the Mall, the wide boulevard that leads to the royal palace as part of the Christmas Jumper Parade. Flossie the dog barks Saturday during the Rescue Dogs of London and Friends Christmas Jumper Parade in central London. Prizes were awarded for best-dressed pets, with contenders including canine Santas, puppy elves and a French bulldog dressed in a red beret and pink jacket adorned with red bows. People and dogs take part in the Rescue Dogs of London and Friends Christmas Jumper Parade on Saturday in central London. The event was organized by Rescue Dogs of London and Friends to raise money for charities that rehome dogs from overseas. People take part in the Rescue Dogs of London and Friends Christmas Jumper Parade on Saturday in central London. Christmas sweater animal parades have become something of an annual tradition in London. People and dogs take part in the Rescue Dogs of London and Friends Christmas Jumper Parade on Saturday outside Buckingham Palace in central London. There are more to come this year, including an event for corgis — the late Queen Elizabeth II's favorite breed — on Dec. 7 and the dachshund-friendly Hyde Park Sausage Walk on Dec 15. From bags of kibble in the grocery store to modern home sizes, things are getting smaller—and evidently, Americans are starting to look for furry friends that match. Small breeds like terriers and toys have largely dethroned the retrievers that once dominated the most popular breed rankings. This is a continuation of a trend that began in 2022 when the Labrador retriever lost its 31-year-long streak as #1 to the French bulldog, according to the American Kennel Club. This shift may be partially attributable to the rising costs of pet products and veterinary care since smaller dogs are more economical for tighter budgets. Moreover, as remote work and nomadic living become increasingly more common, smaller dogs may appeal to those looking for pets that require less space and are easier to transport. In fact, only two sporting dog breeds are the most popular in any American state—and neither is a Labrador retriever. The most popular dog overall represents 4% of all dogs in the country—constituting over 2.3 million out of 58 million households with dogs. used data from to further explore which dog breeds are the most popular in which states and what factors may drive residents' preferences. Named after the northern Mexican state from which it originates, the Chihuahua is the smallest dog breed and one of the oldest, with a lineage that dates as far back as the ninth century. Today, the breed makes up a remarkable 4% of all dogs in the United States and is the most popular overall in 21 states. It ranks within the top five most common breeds in 42 states in total. Requiring just 200 to 250 calories per day but boasting a lifespan of 14 to 16 years, the Chihuahua offers owners low-cost longevity and is known for its adaptability and amusing personality. The French bulldog is a compact companion known for being friendly yet quiet, making it suitable for a range of lifestyles and homes. The breed has roots in the English bulldog, which was bred to a smaller size to accompany its working English owners, many of whom were artisans. As such trades closed amid the Industrial Revolution, these workers and their little bulldogs moved to France, where the breed's popularity began. The French developed a more standardized appearance which was iterated upon in the U.S. to develop the iconic bat ears. The breed has recently seen a massive increase in popularity, with AKC registrations Now, the French bulldog is the most popular dog in Florida, California, and Hawaii and is in the top five most common dogs in nearly half the remaining states. With webbed paws and an affinity for water, golden retrievers are lucky pups to be the favored breed of the Midwest. They are the most popular dogs in states bordering the Great Lakes—Minnesota, Wisconsin, Michigan, Illinois, and Ohio; the entirety of the New England region minus Rhode Island; plus North Dakota, Nebraska, Colorado, and Virginia. The iconic golden breed was developed in 19th-century Scotland to retrieve both from land and water during hunts, hence its swimming-related adaptations. Golden retrievers are known for their affectionate nature and eagerness to please, making them well-suited for service and other working dog roles. As loyal as they are intelligent, German shepherds are among the favored breeds for guide, military, police, and search and rescue roles. The breed, which first arrived in America in the early 20th century, also enjoys peak popularity in Alaska, Montana, Wyoming, Delaware, and Pennsylvania. Athletic in nature, the breed requires lots of exercise, making them well-suited for homes with or near lots of open land. They are also well-adapted to cold temperatures and harsher climates due to their thick double coats of fur. The shih tzu, whose name means "lion" in Chinese, is king of the Empire State (New York) as well as Iowa, Rhode Island, and New Jersey. Roughly a quarter of New York state residents live in apartments, making the dog that averages 9 to 16 pounds perfect for compact households. Despite being known for its playfulness, the breed does not require much physical activity or space. The breed dates back over 1,000 years but was first brought to America surprisingly recently, following World War II. According to the American Kennel Club, every shih tzu alive today has direct lineage to just that were saved when the breed nearly went extinct during the Communist revolution. Representing the best of both worlds, the golden retriever and poodle hybrid is known for its friendly, sociable demeanor and trainability. Bred to be guide dogs in the 1960s, the hybrid is not recognized as an official breed by the AKC, so there is no breed standard. Goldendoodles can thus range from mini-sized to about 90 pounds and may have fur that is curly, straight, or somewhere in between. While not official, the family-friendly dog has left paw prints all over the country, ranking in the top five most popular dogs in 37 states. In Idaho and Utah, the goldendoodle is the most popular overall. Maxing out at just 7 pounds, the Yorkshire terrier is the most popular breed among Maryland and Washington D.C. residents. This is not necessarily surprising considering the housing stock of the nation's capital is comprised mostly of apartment units, making the pint-sized pup perfect for metropolitans. The toy breed was bred to chase rats out of mines and mills in 19th-century England, arriving in North America in the 1870s and gaining official recognition by the AKC in 1885. Now, the breed is among the top five most common dogs in 26 states. The breed is a true terrier at heart, known for its feisty yet affectionate nature.' Receive the latest in local entertainment news in your inbox weekly!Bilawal urges political parties to prioritize dialogue for stability in country
Joco almost died at launch. Now, it’s a lifeline for e-bike delivery riders — and a profitable business