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An Israeli airstrike flattened a multistory building in central Gaza, killing at least 25 people and wounding dozens more, according to Palestinian medical officials, after strikes Thursday across the Gaza Strip killed at least 28 others. The latest deadly strike hit the urban Nuseirat refugee camp just hours after U.S. President Joe Biden’s national security adviser, Jake Sullivan, told reporters in Jerusalem that the recent ceasefire in Lebanon has helped clear the way for a potential deal to end the war in Gaza between Israel and Hamas. The Israeli military did not immediately comment on the deadly strike in Nuseirat. Israel says it is trying to eliminate Hamas, which led the attack on southern Israel in October 2023 that sparked the war in Gaza . The Israeli military says Hamas militants hide among Gaza’s civilian population. The fighting has plunged Gaza into a severe humanitarian crisis, with experts warning of famine in some of the hardest-hit parts of the territory. Israel’s offensive has killed over 44,800 Palestinians in Gaza, more than half of them women and children, according to the Gaza Health Ministry, which does not say how many were combatants. The Israeli military says it has killed over 17,000 militants, without providing evidence. The Oct. 7, 2023 attack by Hamas killed some 1,200 people, mostly civilians, and around 250 others were taken hostage. Some 100 hostages are still inside Gaza, at least a third of whom are believed to be dead. Here's the latest: DAMASCUS, Syria — Mohammad Salim Alkhateb, an official with the National Coalition of Syrian Revolution and Opposition Forces — an internationally backed group of the opposition in exile — said his group wants to see a transitional government formed via a United Nations-backed process in the wake of Bashar Assad ouster. It is not yet clear if Hayat Tahrir al-Sham, the main rebel group now in control of Syria, will pursue such a process. The insurgents have said an interim government headed by Mohammad al-Bashir, who is also the head of the “salvation government” of HTS in its former stronghold in northern Syria, will oversee the country until March but have not made clear how the transition to a new, fully empowered government would take place. “The transitional governing body should be formed in Geneva to have international legitimacy,” said Alkhateb, who is now in Damascus. “The transitional governing body, whatever its form, whether it is the ‘salvation government’ or any other, what matters is that it has international recognition.” Alkhateb said that the unexpectedly rapid fall of Damascus and departure of Assad after opposition forces launched their offensive had created confusion and a governance vacuum. A day before the insurgents pushed into Damascus, diplomats from countries including Saudi Arabia, Qatar, Turkey, Iran and Russia met in Qatar to discuss the situation in Syria. Alkhateb said that they had discussed a scenario in which the rebels would halt their advance, keeping the territory they had captured so far in the north — including Syria’s largest city, Aleppo — and the opposition and Assad’s government would go to Geneva for talks on a political settlement to the conflict. However, he noted, “there were no Syrians in that meeting.” Assad fled to Russia before the rebel forces arrived in Damascus but has not officially announced his resignation, which is “why we are living in a vacuum rather than a political transition,” Alkhateb said. He added that creating a professional army should be a priority of the transitional government. “We do not want a civilian who was trained during the revolution to carry military weapons to become the military,” he said. Israel bombed hundreds of military sites in Syria this week in a wave of airstrikes that destroyed “most of the strategic weapons stockpiles” in the country. Israeli Prime Minister Benjamin Netanyahu said the wave of airstrikes in neighboring Syria was necessary to keep the weapons from being used against Israel following the Syrian government’s stunning collapse . WASHINGTON — White House press secretary Karine Jean-Peirre says Austin Tice, an American journalist missing in Syria for 12 years, “is a top priority for this president.” During a briefing with reporters on Thursday, Jean-Pierre said of Tice, “There is no indication that he is not alive. There’s also no indication about his location or condition.” “What our goal is, is to bring him home. And so, we hope certainly that he is alive and, as we have stated many times before, we are talking through this with the Turks and we want to do everything we can to bring him home,” she said. BEIRUT — Amnesty International said Thursday that four Israeli airstrikes between September and October that killed at least 49 civilians in Lebanon “must be investigated as war crimes.” The rights organization said in a new report that the four strikes targeted homes in the Bekaa Valley, northern and eastern Lebanon, and municipal offices in the south. “These four attacks are emblematic of Israel’s shocking disregard for civilian lives in Lebanon and their willingness to flout international law,” said Amnesty International’s Erika Guevara Rosas, Senior Director for Research, Advocacy, Policy and Campaigns. The rights group said this report was part of its ongoing investigation into violations of the laws of war in Lebanon. Amnesty International investigated four Israeli airstrikes, including one on Sept. 29 in al-Ain that killed all nine members of the same family. On Oct. 21, a strike in Baalbek city in eastern Lebanon killed six members of the same family. Another on Oct. 14 in the village of Aitou in northern Lebanon killed 23 displaced people, including a 5-month-old baby. A fragment from the attack site in Aitou was identified by an Amnesty weapons expert as likely part of a Mk-80 series aerial bomb, weighing at least 500 pounds. These munitions are primarily supplied to Israel by the United States, Amnesty said. The fourth strike Amnesty investigated was the strike that hit the municipal headquarters in Nabatiyeh, southern Lebanon, on Oct. 16, killing 11 civilians including the mayor. “The air strike took place without warning, just as the municipality’s crisis unit was meeting to coordinate deliveries of aid, including food, water and medicine, to residents and internally displaced people who had fled bombardment in other parts of southern Lebanon,” Amnesty said. The rights group said it interviewed survivors and witnesses, examined evidence, and found no military targets near the sites of the four strikes. The Israeli military gave no warnings and did not respond to Amnesty’s inquiries, the group said. DEIR AL-BALAH, Gaza Strip — An Israeli airstrike hit the central Gaza Strip on Thursday, killing at least 25 Palestinians and wounding dozens more, Palestinian medics said, just hours after President Joe Biden’s national security adviser raised hopes about a ceasefire deal to end the war in Gaza. Photos from the scene of the blast that circulated on social media showed a completely collapsed building with people walking through its mangled and charred remains, smoke rising from piles of belongings strewn over the rubble. Officials at two hospitals in the Gaza Strip, al-Awda Hospital in the north and al-Aqsa Hospital in central Gaza, reported they received a combined total of 25 bodies from an Israeli strike on a multistory residential building in the urban Nuseirat refugee camp. Palestinian medics also reported that over 40 people, most of them children, were receiving treatment at the two hospitals. The al-Aqsa Hospital said that the Israeli attack also damaged several nearby houses in Nuseirat. There was no immediate comment from the Israeli military on the deadly strike. Israel is trying to eliminate Hamas, which led the attack on southern Israel in October 2023 that sparked the war in Gaza . The Israeli military says Hamas militants hide among Gaza’s civilian population. Israel’s war against Hamas has killed over 44,800 Palestinians in Gaza, more than half of them women and children, according to the Gaza Health Ministry, which does not say how many were combatants. The Israeli military says it has killed over 17,000 militants, without providing evidence. The fighting has plunged Gaza into a severe humanitarian crisis, with experts warning of famine. Israel says it allows enough aid to enter and blames U.N. agencies for not distributing it. The U.N. says Israeli restrictions, and the breakdown of law and order after Israel repeatedly targeted the Hamas-run police force, make it extremely difficult to operate in the territory. UNITED NATIONS – The U.N. food agency is trying to deal with massive needs in Syria not only from escalating war-related food insecurity and an upsurge in displaced people fleeing Lebanon but also the dramatically new environment following the ouster of Bashar Assad, a senior U.N. official says. “It’s a triple crisis and the needs are going to be massive,” said Carl Skau, deputy executive director of the World Food Program, in an interview with The Associated Press late Wednesday. The WFP estimated that 3 million people in Syria were “acutely food insecure” and very hungry. However, that estimate was made before the Israel-Hezbollah war in Lebanon pushed many Syrian refugees back to their home country, plus the instability caused by the overthrow of Assad. Due to funding cuts, the WFP had been targeting only 2 million of those people, he said. Because WFP has been working in Syria during the 13-year civil war, he said, it has pre-positioned food in the country. It has 500 staff in seven offices nationwide and has operated across conflict lines, across borders, and with all different parties, he said. Skau said Hayat Tahrir al-Sham, the main rebel group now in control of Syria, has promised to provide security for WFP warehouses. Humanitarian aid supplies had been looted at U.N. warehouses in the disorder after Assad fell. “We’re not really up and running in Damascus because of the continued kind of uncertainty there,” he said. WFP initially thought of relocating non-essential staff but the situation in Aleppo, Syria’s largest city, has been “quite calm and orderly," he said. In the short term, Skau said, “what we’re seeing is that markets are disrupted, the value of the currency dropped dramatically, food prices are going up, transport lines don’t work,” and it’s unclear who will stamp required papers for imports and exports. This means that a bigger humanitarian response is needed initially, he said, but in the next phase, the U,N. will be looking at contributing to Syria’s recovery, and ultimately the country will need reconstruction. Skau said he expects a new funding appeal for Syria and urged donors to be generous. JERUSALEM — President Joe Biden’s national security adviser, Jake Sullivan, told reporters in Jerusalem on Thursday that Israel’s ceasefire in Lebanon has helped clear the way for another deal to end the war in Gaza. He plans to travel next to Qatar and Egypt — key mediators in the ceasefire talks — as the Biden administration makes a final push on negotiations before Donald Trump is inaugurated. Sullivan said “Hamas’ posture at the negotiating table did adapt” after Israel decimated the leadership of its ally Hezbollah in Lebanon and reached a ceasefire there. “We believe it puts us in a position to close this negotiation,” he said. Sullivan dismissed speculation that Israeli Prime Minister Benjamin Netanyahu was waiting for Trump to take office to finalize a deal. He the U.S. believes there are three American hostages still alive in Gaza, but it’s hard to know for sure. He also said “the balance of power in the Middle East has changed significantly” since Hamas’ Oct. 7 attack on Israel, especially with the overthrow of former Syrian President Bashar Assad, a key ally of Hezbollah and Iran. “We are now faced with a dramatically reshaped Middle East in which Israel is stronger, Iran is weaker, its proxies decimated, and a ceasefire that is new and will be lasting in Lebanon that ensures Israel’s security over the long term,” he said. KHIAM, Lebanon — An Israeli strike killed at least one person Thursday in the Lebanese border town of Khiam, the Health Ministry said, less than a day after Israeli troops handed the hilltop village back to the Lebanese army in coordination with U.N. peacekeepers, Khiam is the first Lebanese town Israel has pull out of since a ceasefire between Israel and Hezbollah militants began two weeks ago, and marks an important test of the fragile truce . Lebanon's Health Ministry and state news agency did not provide details on who was killed, and did not report airstrikes elsewhere on Thursday. The Israeli military said the airstrike in Khiam targeted Hezbollah fighters. Lebanese troops deployed in the northern section of the town on Thursday morning and were coordinating with U.N. peacekeepers to finalize Israel’s withdrawal before fully entering into other neighborhoods. An Associated Press reporter who visited Khiam on Thursday observed widespread destruction, with most houses reduced to rubble. Entire neighborhoods were flattened, with collapsed walls and debris scattered across the streets. Lebanon’s caretaker prime minister, Najib Mikati, sharply criticized Israel for striking the town less than 24 hours after the Lebanese army returned, saying it was “a violation of the pledges made by the parties that sponsored the ceasefire agreement, who must act to curb Israeli aggression.” The truce was brokered by the U.S. and France. Israel has previously said the ceasefire deal allows it to use military force against perceived violations. Near-daily attacks by Israel during the ceasefire, mostly in southern Lebanon, have killed at least 29 people and wounded 27 others. Khiam, which sits on a ridge less than 3 miles (5 kilometers) from the border with Israel, saw some of the most intense fighting during the war. The Lebanese army was clearing debris and reopening roads in the northern section of the town. Civilian access to other areas remained challenging as the army clears roads and works alongside the U.N. peacekeepers to ensure the area is free of unexploded ordnance. AQABA, Jordan -- U.S. Secretary of State Antony Blinken is urging the many players in Syria to avoid taking any steps that could lead to further violence. Blinken spoke to reporters in Jordan on Thursday shortly after meeting King Abdullah II as he opened a trip in the region to discuss Syria's future after former President Bashar Assad's ouster. Blinken will next visit Turkey, a NATO ally and a main backer of Syrian rebel groups. Blinken called this “a time of both real promise but also peril for Syria and for its neighbors.” He said he was focused on coordinating efforts in the region “to support the Syrian people as they transition away from Assad’s brutal dictatorship” and establish a government that isn’t dominated by one religion or ethnic group or outside power. Blinken was asked about Israel’s incursion into a buffer zone that had been demilitarized for the past half century. Israeli Prime Minister Benjamin Netanyahu says the move is temporary and defensive, but also indicated Israel will remain in the area for a long time. Blinken declined to say whether the U.S. supports the move, but said the U.S. would be speaking to Israel and other partners in the region. “I think, across the board, when it comes to any actors who have real interests in Syria, it’s also really important at this time that, we all try to make sure that we’re not sparking any additional conflicts,” he said. ANKARA, Turkey — Turkey’s intelligence chief, Ibrahim Kalin, arrived in Damascus on Thursday, according to Turkish media reports. Kalin was seen arriving at the Umayyad Mosque to pray, surrounded by a large crowd, according to video shown on Turkish television. The visit is highly symbolic. Turkish officials, who supported the opposition against Syria’s government, had predicted at the start of the civil war in 2011 that President Bashar Assad’s government would fall, allowing them to pray at the Umayyad Mosque. JERUSALEM — Paraguay reopened its embassy in Jerusalem Thursday, becoming one of a small handful of nations to recognize the city as Israel’s capital and marking a diplomatic victory for Prime Minister Benjamin Netanyahu. Israel’s international isolation has increased as the war in Gaza drags on, and Paraguay was the first country to move its embassy to Jerusalem since the Oct. 7, 2023 Hamas attack that kickstarted the war. The United States, Honduras, Guatemala, Kosovo, and Papua New Guinea are among the few countries with Jerusalem embassies. Israel annexed east Jerusalem in 1967 but it wasn’t recognized by the international community, and most countries run their embassies out of Tel Aviv. Spirits were high at the ceremony marking the embassy’s inauguration Thursday, with Netanyahu and Israel’s Foreign Minister Gideon Saar lavishing praise on Paraguayan President Santiago Pena. “My good friend Santiago,” said Netanyahu, addressing Pena. “We’re a small nation. You’re a small nation. We suffered horrible things but we overcame the odds of history...we can win and we are winning.” Paraguay had an embassy in Jerusalem in 2018, under Former President Horacio Cartes. That embassy was moved back to Tel Aviv by Cartes’ successor, Mario Abdo Benitez, prompting Israel to close its embassy in Asuncion. Saar said Israel and Paraguay shared a “friendship based not only on interests but also values and principles.” He and the Paraguayan foreign minister, Rubén Ramírez Lezcano, signed a series of bilateral agreements and Saar said he would soon visit Asunción with a delegation from the Israeli private sector. “Israel is going to win and the countries we are standing next to Israel, we are going to win," Pena said. AQABA, Jordan — U.S. Secretary of State Antony Blinken is renewing calls for Syria’s new leadership to respect women and minority rights, prevent extremists from gaining new footholds in the country and keeping suspected chemical weapons stocks secure as he makes his first visit to the Mideast since the weekend ouster of Syrian President Bashar Assad . Making his 12th trip to the Middle East since the Israel-Hamas war erupted lasted year but amid fresh concerns about security following the upheaval in Syria, Blinken emphasized Thursday to Jordan’s King Abdullah II U.S. “support for an inclusive transition that can lead to an accountable and representative Syrian government chosen by the Syrian people,” the State Department said. Blinken also repeated the importance the outgoing Biden administration puts on respect for human rights and international law, the protection of civilians and stopping terrorist groups from reconstituting. Blinken met with the monarch and Jordanian Foreign Minister Ayman Safadi in Aqaba before traveling to Turkey for talks with Turkish officials on the situation in Syria and the urgency of securing a long-elusive deal to release hostages and end the fighting in Gaza that has devastated the Palestinian territory since October 2023. Abdullah told Blinken that “the first step to reach comprehensive regional calm is to end the Israeli war on Gaza." GENEVA — The U.N. envoy for Syria is calling on authorities to save evidence from detention centers that were a hub of “unimaginable barbarity” that Syrians have faced for many years and cooperate with international investigators looking into such crimes. Geir Pederson referred to new images from the notorious Saydnaya military prison north of the capital, Damascus, after President Bashar Assad fled Syria as armed groups stormed in to overthrow his government over the weekend. “The images from Saydnaya and other detention facilities starkly underscore the unimaginable barbarity Syrians have endured and reported for years,” Pedersen said in a statement. Documentation and testimonies “only scratch the surface of the carceral system’s horrors,” he added. Pedersen urged authorities to cooperate with U.N. bodies like an independent Commission of Inquiry on Syria, which was created in 2011, and an independent group known as the IIIM that was set up five years later to also compile evidence of crimes. ROME — Leaders of the Group of 7 industrialized nations offered their full support for an inclusive political transition in Syria and invited all parties to preserve the country’s territorial integrity. In a message released by Italian Premier Giorgia Meloni’s office, the leaders said they were ready to support a transition that “leads to a credible government, inclusive and not sectarian, that guarantees respect for the state of law, universal human rights, including rights for women, (and) the protection of all Syrians, including religious and ethnic minorities.” The leaders also underlined the importance that ousted President Bashar Assad’s government is held responsible for crimes, citing “decades of atrocities.” They said they would also cooperate with groups working to prohibit chemical weapons “to secure, declare and destroy” remaining chemical arms in Syria. Italy currently holds the rotating presidency of the G-7, which also includes Britain, Canada, France, Germany, Japan and the United States. JERUSALEM — The Israeli military says it struck Hamas militants in two locations in the southern Gaza Strip who planned to hijack aid convoys. Palestinian Health officials had earlier said that the two strikes killed 15 men who were part of local committees established to secure aid deliveries. The committees have been organized in cooperation with the Hamas-run Interior Ministry in Gaza. It was not possible to independently confirm either account of the strikes, which occurred overnight into Thursday. Israel has long accused Hamas of hijacking humanitarian aid deliveries, while U.N. officials have said there is no systemic diversion of aid . U.N. agencies and aid groups say deliveries are held up by Israeli restrictions on the entry of aid and movement within Gaza, as well as the breakdown of law and order more than 14 months into the war between Israel and Hamas. Israel has repeatedly targeted the Hamas-run police force, which maintained internal security before the war. The United Nations agency for Palestinian refugees, the main aid provider in Gaza, said a U.N. convoy of 70 trucks carrying humanitarian aid in southern Gaza “was involved in a serious incident,” resulting in just one of the trucks reaching its destination. It did not provide further details on the incident but said the same route had been used successfully two days earlier. Israel’s offensive, launched after Hamas’ Oct. 7, 2023, attack, has caused vast destruction and displaced around 90% of Gaza’s population of 2.3 million, leaving the territory heavily reliant on international food aid. DAMASCUS, Syria — An American who turned up in Syria on Thursday says he was detained after crossing into the country by foot on a Christian pilgrimage seven months ago. Travis Timmerman appears to have been among thousands of people released from the country’s notorious prisons after rebels reached Damascus over the weekend, overthrowing President Bashar Assad and ending his family’s 54-year rule. As video emerged online of Timmerman on Thursday, he was initially mistaken by some for Austin Tice, an American journalist who went missing in Syria 12 years ago. In the video, Timmerman could be seen lying on a mattress under a blanket in what appeared to be a private house. A group of men in the video said he was being treated well and would be safely returned home. The Biden administration is working to bring Timmerman home, Secretary of State Antony Blinken told reporters in Aqaba, Jordan, without offering details, citing privacy. Timmerman later gave an interview with the Al-Arabiya TV network, saying he had illegally crossed into Syria on foot from the eastern Lebanese town of Zahle seven months ago, before being detained. He said he was treated well in detention but could hear other men being tortured. AQABA, Jordan — U.S. Secretary of State Antony Blinken has arrived in Jordan on his 12th visit to the Mideast since the Israel-Hamas war erupted last year and his first since the weekend ouster of Syrian President Bashar Assad that has sparked new fears of instability in a region wracked by three conflicts despite a ceasefire agreement in Lebanon. Blinken was meeting in Aqaba with Jordan’s King Abdullah II and Foreign Minister Ayman Safadi on Thursday before traveling to Turkey for talks with Turkish officials on Friday. The meetings will focus largely on Syria but also touch on long-elusive hopes for a deal to end the fighting in Gaza that has devastated the Palestinian territory since October 2023. Blinken is the latest senior U.S. official to visit the Middle East in the five days since Assad was deposed as the Biden administration navigates more volatility in the region in its last few weeks in office and as President-elect Donald Trump has said the U.S. should stay out of the Syrian conflict. Other include national security adviser Jake Sullivan and a top military commander who traveled there as the U.S. and Israel have launched airstrikes to prevent the Islamic State militant group from reconstituting and prevent materiel and suspected chemical weapons stocks from falling into militant hands. Blinken “will discuss the need for the transition process and new government in Syria to respect the rights of minorities, facilitate the flow of humanitarian assistance, prevent Syria from being used as a base of terrorism or posing a threat to its neighbors, and ensure that chemical weapons stockpiles are secured and safely destroyed,” the State Department said. The U.S. would be willing to recognize and fully support a new Syrian government that met those criteria. U.S. officials say they are not actively reviewing the foreign terrorist organization designation of the main Syrian rebel group, Hayat Tahrir al-Sham, known as HTS, which was once an al-Qaida affiliate, but stressed they are not barred from speaking to its members. JERUSALEM — Israeli Prime Minister Benjamin Netanyahu says Israeli forces will remain in a Syrian buffer zone until a new force on the other side of the border can guarantee security. After the overthrow of Syrian President Bashar Assad, Israeli forces pushed into a buffer zone that had been established after the 1973 Mideast war. The military says it has seized additional strategic points nearby. Israeli officials have said the move is temporary, but Netanyahu’s conditions could take months or even years to fulfill as Syria charts its post-Assad future, raising the prospect of an open-ended Israeli presence in the country. Netanyahu’s office said in a statement Thursday that Assad’s overthrow by jihadi rebels created a vacuum on the border. “Israel will not permit jihadi groups to fill that vacuum and threaten Israeli communities on the Golan Heights with October 7th style attacks,” it said, referring to Hamas’ 2023 attack out of Gaza, which ignited the war there. “That is why Israeli forces entered the buffer zone and took control of strategic sites near Israel’s border.” The statement added that “this deployment is temporary until a force that is committed to the 1974 agreement can be established and security on our border can be guaranteed.” The buffer zone is adjacent to the Golan Heights, which Israel captured from Syria in the 1967 Mideast war and later annexed. The international community, except for the United States, views the Golan as occupied Syrian territory. JERUSALEM — Israel’s military said Thursday that the attacker who fatally shot a 12-year-old Israeli boy in the occupied West Bank overnight turned himself in to authorities. The attacker opened fire on a bus near the Israeli settlement of Beitar Illit, critically wounding the boy, who hospital authorities pronounced dead in the early morning. Three others were wounded in the attack, paramedics said. The shooting took place just outside Jerusalem in an area near major Israeli settlements. JAKARTA, Indonesia — The Indonesian government has evacuated 37 citizens from Syria following the fall of the Bashar al-Assad government, officials said Thursday. The evacuees were taken by land from Damascus to Beirut, where they boarded three commercial flights to Jakarta, said Judha Nugraha, director of citizen protection at the Foreign Affairs Ministry. The Indonesian Embassy in Damascus said all 1,162 Indonesian citizens in Syria were safe. Indonesian Ambassador to Syria Wajid Fauzi said the situation in Syria has gradually returned to normal. “I can say that 98% of people’s lives are back to normal, shops are open, public transportation has started running,” Fauzi said, adding that most Indonesian nationals living in Syria had chosen to stay. DEIR AL-BALAH, Gaza Strip — Palestinian medical officials say Israeli airstrikes have killed at least 28 people in the Gaza Strip, including seven children and a woman. One of the strikes overnight and into Thursday flattened a house in the built-up Nuseirat refugee camp, according to the Al-Aqsa Martyrs Hospital in the nearby city of Deir al-Balah, where the casualties were taken. An Associated Press reporter saw the bodies at the hospital’s morgue. Two other strikes killed 15 men who were part of local committees established to secure aid convoys . The committees were set up by displaced Palestinians in coordination with the Hamas-run Interior Ministry. The Nasser Hospital in the southern city of Khan Younis received the bodies and an AP reporter counted them. The hospital said eight were killed in a strike near the southern border town of Rafah and seven others in a strike 30 minutes later near Khan Younis. The war in Gaza began when Hamas-led militants attacked southern Israel on Oct. 7, 2023, killing some 1,200 people, mostly civilians, and abducting around 250 people. Some 100 hostages are still inside Gaza, at least a third of whom are believed to be dead. Israel’s offensive has killed over 44,800 Palestinians in Gaza, more than half of them women and children, according to the Gaza Health Ministry, which does not say how many were combatants. The Israeli military says it has killed over 17,000 militants, without providing evidence. The fighting has plunged Gaza into a severe humanitarian crisis, with experts warning of famine. Israel says it allows enough aid to enter and blames U.N. agencies for not distributing it. The U.N. says Israeli restrictions, and the breakdown of law and order after Israel repeatedly targeted the Hamas-run police force, make it extremely difficult to operate in the territory. UNITED NATIONS — The U.N. General Assembly overwhelmingly approved resolutions Wednesday demanding an immediate ceasefire in Gaza and backing the U.N. agency for Palestinian refugees that Israel has moved to ban . The votes in the 193-nation world body were 158-9 with 13 abstentions to demand a ceasefire now and 159-9 with 11 abstentions to support the agency known as UNRWA. The votes culminated two days of speeches overwhelmingly calling for an end to the 14-month war between Israel and the militant Hamas group . General Assembly resolutions are not legally binding, though they reflect world opinion. There are no vetoes in the assembly. Israel and its close ally, the United States, were in a tiny minority speaking and voting against the resolutions.Union announce offseason roster moves, part with Leon FlachReport: Institutional neutrality favored at Carolina, Wake, Duke
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Lidocaine is under clinical development by MEDRx and currently in Pre-Registration for Postherpetic Neuralgia. According to GlobalData, Pre-Registration drugs for Postherpetic Neuralgia have an 83% phase transition success rate (PTSR) indication benchmark for progressing into Marketed. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Lidocaine overview lidocaine (MRX-5LBT) is under development for the treatment nerve pain associated with shingles (post-herpetic neuralgia, a severe neuropathic pain condition). The therapeutic candidate is administered transdermally which is formulated as patch. The development of the drug candidate is based on the ionic liquid transdermal system (ILTS) technology. MEDRx overview MEDRx through its subsidiaries carries out development of pharmaceutical drug based on the transdermal absorption system. The company’s pipeline products include CPN-101 (MRX-4TZT) treats pasticity; MRX-5LBT is for the treatment of neuropathic pain; MRX-9FLT and MRX-10XT for moderate to severe pain; MRX-7MLL targets alzheimer’s disease; MRX-6LDT for Chronic Pain; ALT-101 treats schizophrenia. It partners with many pharmaceutical companies for development of various drugs. The company operates across the US and Japan. MEDRx is headquartered in Higashikagawa City, Japan. For a complete picture of Lidocaine’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .
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6,000 inmates escape from a high-security prison as post-election violence roils MozambiqueOjiezele Osezua Sunday, the lawmaker representing Esan South-East Constituency on the platform of the People’s Democratic Party (PDP) in Edo State House of Assembly, has said that his defection to the All Progressives Congress (APC) is in line with the 1999 Constitution of the Federal Republic of Nigeria as amended. Osezua defected to the ruling APC party in the State on Monday at the Party’s Secretariat in Benin City. The two-time lawmaker noted that Section 109, Subsection (1) G, of the Constitution of the Federal Republic of Nigeria, permits him to leave his party when there are irreconcilable differences. “Section 109, Subsection (1)G, is that the only reason you can leave your party is when there are irreconcilable differences. The PDP that sponsored my second tenure election is into that challenge”, he said. He said the division in his former party, PDP, had given him room to join the All Progressives Party (APC) to pay the debts owed the party. Osezua was first elected to the State House of Assembly between 2019 and 2023 on the platform of APC. He, however, defected to the PDP in 2020 alongside the immediate past governor of the State, Godwin Obaseki. He was also among the 10 lawmakers that were inaugurated by the former Governor Obaseki at night. His defection to APC came barely three months after his party, PDP lost the Governorship Election conducted on September 21, 2024, in the State to the former. Speaking during the defection, he said he was leaving his party to join the APC. While describing his defection as a homecoming, he said he was leaving the PDP due to irreconcilable differences in the State and at the national level. He also hinged his defection on the debt he owed the APC that must be paid. He, however, thanked the members of the State executive council of the party for receiving him. “In 2019, APC was the ladder that brought me to the Assembly but unfortunately we have some challenges which led us into PDP in the company of the immediate past governor. “Today, I am still indebted to the APC, because having sponsored me, I was supposed to spend four years but I only spent one year before I left, which means I am still indebted to the APC. “Today defection is the debt I have come to repay”, he added. Receiving the defected lawmaker to the party, Jarret Tenebe, the Acting State Chairman of APC, lauded the legislator for joining the party, saying “More people will defect to the party in the coming months. “It is not the fault of APC for PDP to have a crisis in their party that will make their members cross the carpet and today we are happy. You will recall that during the election campaigns, I said our doors are opened and the door is still open.”
Meet man who studied at IIT Delhi, quit without completing his degree, he is now owner of a company worth Rs...Khanewal leader commends Punjab govt’s sports facilities
With glass domes for stargazing and expensive price tags to stay the night, the ambitious plan falls snugly into the category of "luxury ecotourism." Click to share on Facebook (Opens in new window) Click to share on X (Opens in new window) Most Popular Colonial Williamsburg’s Grand Illumination has echoes across the US Colonial Williamsburg's Grand Illumination has echoes across the US Woman dies, driver injured in James City County crash Woman dies, driver injured in James City County crash House approves $895B defense bill with military pay raise, ban on transgender care for minors House approves $895B defense bill with military pay raise, ban on transgender care for minors Bill Belichick agrees to become North Carolina head football coach Bill Belichick agrees to become North Carolina head football coach Former NFL player opens Newport News youth empowerment center Former NFL player opens Newport News youth empowerment center Phoebus’ football seniors want 4th state title, designation as ‘The Dynasty Class’ Phoebus’ football seniors want 4th state title, designation as ‘The Dynasty Class’ Kingsmill residents address James City County officials with concerns about future development Kingsmill residents address James City County officials with concerns about future development Cause of underground fire at Williamsburg Premium Outlets still unknown — and may stay that way, fire chief says Cause of underground fire at Williamsburg Premium Outlets still unknown — and may stay that way, fire chief says Head of the Federal Aviation Administration to resign, allowing Trump to pick his successor Head of the Federal Aviation Administration to resign, allowing Trump to pick his successor FBI Director Christopher Wray says he intends to resign at the end of Biden’s term next month FBI Director Christopher Wray says he intends to resign at the end of Biden’s term next month Trending Nationally Hannah Kobayashi, missing Hawaii woman who prompted a massive search, is found safe Kimberly Guilfoyle: Latest Trump nominee accused of sexual misconduct Baseball slugger and former Cleveland Indians All-Star Rocky Colavito passes away NYC wanted posters target CEOs in wake of United Healthcare CEO Brian Thompson slay ALDI has come up with a better way on shopping cartsFlorida-Based International Transactions Team Joins Ice Miller to Launch New Miami OfficeRestaurateur 'King of Mayfair' Richard Caring launching major campaign to help victims of domestic violence
Manmohan Singh News: Former India cricketers among the likes of Harbhajan Singh, VVS Laxman, Virender Sehwag and Yuvraj Singh took to social media to pay condolences on the demise of former Prime Minister Manmohan Singh. Manmohan Singh passed away on Thursday night at the age of 92 due to age-related medical conditions, AIIMS informed. He had a sudden loss of consciousness at home after which he was rushed to the AIIMS Delhi. "With profound grief, we inform the demise of former Prime Minister Dr Manmohan Singh, aged 92. He was being treated for age-related medical conditions and had sudden loss of consciousness at home on 26th December 2024. Resuscitative measures were started immediately at home. He was brought to the Medical Emergency at AIIMS, New Delhi at 8:06 PM. Despite all efforts, he could not be revived and was declared dead at 9:51 PM," AIIMS said in a press release. Harbhajan took to X and expressed his sadness on the demise of former Prime Minister and wrote, "Saddened by the news of sudden demise of former Prime Minister, a thorough gentleman, and a visionary leader, Dr. Manmohan Singh Ji" Saddened by the news of sudden demise of former Prime Minister, a thorough gentleman, and a visionary leader, Dr. Manmohan Singh Ji 💔💔What truly set him apart was his calm and steady leadership in times of crisis, his ability to navigate complex political landscapes, and his... pic.twitter.com/WKbjrnADJQ "What truly set him apart was his calm and steady leadership in times of crisis, his ability to navigate complex political landscapes, and his unwavering belief in India's potential. Nation will always remember Dr. Saheb for his contributions. My deepest condolences to his family and relatives. Satnam Waheguru," Harbhajan added. "My heartfelt condolences on the passing away of our former Prime Minister Shri Manmohan Singh ji. Om Shanti," Sehwag wrote on X. My heartfelt condolences on the passing away of our former Prime Minister Shri Manmohan Singh ji. Om Shanti 🙏🏼 pic.twitter.com/uPkmiCm5C4 "Sad to learn about the demise of our former Prime Minister Shri Manmohan Singh ji. Heartfelt condolences to his family and loved ones. On Shanti," Laxman wrote on X. Sad to learn about the demise of our former Prime Minister Shri Manmohan Singh ji. Heartfelt condolences to his family and loved ones. On Shanti 🙏🏼 pic.twitter.com/09tKVnUBdf "Sad news of the passing of Dr. Manmohan Singh Ji. A visionary leader and a true statesman who worked tirelessly for India's progress. His wisdom and humility will always be remembered. My heartfelt condolences to his loved ones," Yuvraj wrote on X. Sad news of the passing of Dr. Manmohan Singh Ji. A visionary leader and a true statesman who worked tirelessly for India’s progress. His wisdom and humility will always be remembered. My heartfelt condolences to his loved ones. 🙏 #ManmohanSingh ji Manmohan Singh, born in Punjab in 1932, served two terms as Prime Minister of India- from 2004 to 2014. He took the oath of office for the first time in 2004, after Congress' win in the 2004 Lok Sabha election against Atal Bihari Vajpayee-led NDA. He served his second term from 2009 to 2014. He was then succeeded by PM Narendra Modi in 2014. He retired from the Rajya Sabha earlier this year after serving for 33 years in the house.From AI Visionary to Industry Leader: Himanshu Sinha on Transforming Enterprises with Machine Learning and Generative AI
Australia’s House of Representatives passes bill that would ban young children from social mediaWithin days of Donald Trump’s election victory, health care entrepreneur Calley Means turned to social media to crowdsource advice. “First 100 days,” said Means, a former consultant to Big Pharma who uses the social platform X to focus attention on chronic disease. “What should be done to reform the FDA?” The question was more than rhetorical. Means is among a cadre of health business leaders and nonmainstream doctors who are influencing President Donald Trump’s focus on health policy. Trump’s return to the White House has given Means and others in this space significant clout in shaping the nascent health policies of the new administration and its federal agencies. It’s also giving newfound momentum to “Make America Healthy Again,” or MAHA, a controversial movement that challenges prevailing thinking on public health and chronic disease. Its followers couch their ideals in phrases like “health freedom” and “true health.” Their stated causes are as diverse as revamping certain agricultural subsidies, firing National Institutes of Health employees, rethinking childhood vaccination schedules, and banning marketing of ultra-processed foods to children on TV. Public health leaders say the emerging Trump administration’s interest in elevating the sometimes unorthodox concepts could be catastrophic, eroding decades of scientific progress while spurring a rise in preventable disease. They worry the administration’s support could weaken trust in public health agencies. Georges Benjamin, executive director of the American Public Health Association, said he welcomes broad intellectual scientific discussion but is concerned that Trump will parrot untested and unproven public health ideas he hears as if they are fact. Experience has shown that people with unproven ideas will have his ear and his “very large bully pulpit,” he said. “Because he’s president, people will believe he won’t say things that aren’t true. This president, he will.” But those in the MAHA camp have a very different take. They say they have been maligned as dangerous for questioning the status quo. The election has given them an enormous opportunity to shape politics and policies, and they say they won’t undermine public health. Instead, they say, they will restore trust in federal health agencies that lost public support during the pandemic. “It may be a brilliant strategy by the right,” said Peter McCullough, a cardiologist who has come under fire for saying COVID-19 vaccines are unsafe. He was describing some of the election-season messaging that mainstreamed their perspectives. “The right was saying we care about medical and environmental issues. The left was pursuing abortion rights and a negative campaign on Trump. But everyone should care about health. Health should be apolitical.” The movement is largely anti-regulatory and anti-big government, whether concerning raw milk or drug approvals, although implementing changes would require more regulation. Many of its concepts cross over to include ideas that have also been championed by some on the far left. Robert F. Kennedy Jr., an anti-vaccine activist Trump has nominated to run the Department of Health and Human Services, has called for firing hundreds of people at the National Institutes of Health, removing fluoride from water, boosting federal support for psychedelic therapy, and loosening restrictions on raw milk, consumption of which can expose consumers to foodborne illness. Its sale has prompted federal raids on farms for not complying with food safety regulations. Means has called for top-down changes at the U.S. Department of Agriculture, which he says has been co-opted by the food industry. Though he himself is not trained in science or medicine, he has said people had almost no chance of dying of COVID-19 if they were “metabolically healthy,” referring to eating, sleeping, exercise and stress management habits, and has said that about 85 percent of deaths and health care costs in the U.S. are tied to preventable foodborne metabolic conditions. A co-founder of Truemed, a company that helps consumers use pretax savings and reimbursement programs on supplements, sleep aids, and exercise equipment, Means says he has had conversations behind closed doors with dozens of members of Congress. He said he also helped bring RFK Jr. and Trump together. RFK Jr. endorsed Trump in August after ending his independent presidential campaign. “I had this vision for a year, actually. It sounds very woo-woo, but I was in a sweat tent with him in Austin at a campaign event six months before, and I just had this strong vision of him standing with Trump,” Means said recently on the Joe Rogan Experience podcast. The former self-described never-Trumper said that, after Trump’s first assassination attempt, he felt it was a powerful moment. Means called RFK Jr. and worked with conservative political commentator Tucker Carlson to connect him to the former president. Trump and RFK Jr. then had weeks of conversations about topics such as child obesity and causes of infertility, Means said. “I really felt, and he felt, like this could be a realignment of American politics,” Means said. He is joined in the effort by his sister, Casey Means, a Stanford University-trained doctor and co-author with her brother of “Good Energy,” a book about improving metabolic health. The duo has blamed Big Pharma and the agriculture industry for increasing rates of obesity, depression and chronic health conditions in the country. They have also raised questions about vaccines. “Yeah, I bet that one vaccine probably isn’t causing autism, but what about the 20 that they are getting before 18 months,” Casey Means said in the Joe Rogan podcast episode with her brother. The movement, which challenges what its adherents call “the cult of science,” gained significant traction during the pandemic, fueled by a backlash against vaccine and mask mandates that flourished during the Biden administration. Many of its supporters say they gained followers who believed they had been misled on the effectiveness of COVID-19 vaccines. In July 2022, Deborah Birx, COVID-19 response coordinator in Trump’s first administration, said on Fox News that “we overplayed the vaccines,” although she noted that they do work. Anthony Fauci, who advised Trump during the pandemic, in December 2020 called the vaccines a game changer that could diminish COVID-19 the way the polio vaccine did for that disease. Eventually, though, it became evident that the shots don’t necessarily prevent transmission and the effectiveness of the booster wanes with time, which some conservatives say led to disillusionment that has driven interest in the health freedom movement. Federal health officials say the rollout of the COVID vaccine was a turning point in the pandemic and that the shots lessen the severity of the disease by teaching the immune system to recognize and fight the virus that causes it. Postelection, some Trump allies such as Elon Musk have called for Fauci to be prosecuted. Fauci declined to comment. Joe Grogan, a former director of the White House’s Domestic Policy Council and assistant to Trump, said conservatives have been trying to articulate why government control of health care is troublesome. “Two things have happened. The government went totally overboard and lied about many things during COVID and showed no compassion about people’s needs outside of COVID,” he said. “RFK Jr. came along and articulated very simply that government control of health care can’t be trusted, and we’re spending money, and it isn’t making anyone healthier. In some instances, it may be making people sicker.” The MAHA movement capitalizes on many of the nonconventional health concepts that have been darlings of the left, such as promoting organic foods and food as medicine. But in an environment of polarized politics, the growing prominence of leaders who challenge what they call the cult of science could lead to more public confusion and division, some health analysts say. Jeffrey Singer, a surgeon and senior fellow at the Cato Institute, a libertarian public policy research group, said in a statement that he agrees with RFK Jr.’s focus on reevaluating the public health system. But he said it comes with risks. “I am concerned that many of RFK Jr.’s claims about vaccine safety, environmental toxins and food additives lack evidence, have stoked public fears and contributed to a decline in childhood vaccination rates,” he said. Measles vaccination among kindergartners in the U.S. dropped to 92.7 percent in the 2023-24 school year from 95.2 percent in the 2019-20 school year, according to the Centers for Disease Control and Prevention. The agency said that has left about 280,000 kindergartners at risk.
CHICAGO (AP) — The Seattle Seahawks placed running back Kenneth Walker III on injured reserve prior to their game against the Chicago Bears on Thursday because of an ankle injury. Walker hurt his ankle in last week's loss to Minnesota and left that game after sitting out the previous two because of a calf problem. He also missed two weeks in September with an oblique issue. Walker has run for 573 yards and seven touchdowns on 153 carries. A second-round draft pick by Seattle in 2022, he has 2,528 yards rushing and 24 TDs in his career. Walker could, in theory, return if the Seahawks win two playoff games, though their postseason hopes were slim entering the game against Chicago. Seattle (8-7) trailed the NFC West-leading Los Angeles Rams (9-6) by one game with two to play. The Seahawks' best path to the postseason was to win the final two regular-season games and have Los Angeles lose to Arizona on Saturday. Seattle visits the Rams to close the regular season. With Walker out, Seattle signed rookie running back George Holani off the practice squad. ___ AP NFL: https://apnews.com/hub/NFLExcerpts from Manmohan Singh’s 1991 budget address: The problem, the path and the pain...Prince William's royal equerry is stepping down following four years of service
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A columnist took a humorous look at the Christmas wish list of Donald Trump and other prominent political figures. The president-elect apparently wants Canada , Mexico , Greenland and the Panama Canal, wrote Salon's Brian Karem , and wondered what Trump wanted to do with those sovereign territories he's been talking about taking over. "Perhaps taking over Canada and Mexico is just Trump’s way of solving the so-called immigration crisis," Karem wrote. "Taking back the Panama Canal would enable him to charge exorbitant fees for retail traffic through the canal zone (so he could pay his personal legal bills) – and taking over Greenland will give him plenty of room for his new gulags he wishes to build to house Liz Cheney, Adam Kinzinger, Dr. Anthony Fauci, and scores of others on his enemies list. Maybe he can even let the largest private prison companies run the new gulags at a well-negotiated price and for massive profits (of which he’ll take a personal cut)." ALSO READ: Why ABC settled a case they knew they would win — and why the Lincoln Project didn't Karem then turned his attention to vice president-elect J.D. Vance and the purportedly apparent co-president Elon Musk. "Vance wants to be taken seriously this Christmas season, but I doubt Santa Claus has Vance’s manhood in his bag of goodies," Karem wrote. "Vance emerged from obscurity this week after being overwhelmed by the presence of Trump’s favorite puppeteer, Elon Musk. Vance was seen on Capitol Hill helping to negotiate a budget deal that would keep the government running until March. After the deal was done, Vance disappeared back into the night ether from which he came. Rumor is he’ll stay in his coffin until he’s needed." Musk seemingly wants the entire world for Christmas , the columnist wrote, so he can cover it "in a white supremacist cloak that will make the Nazi regime look like a PTA meeting circle jerk." "His international reach continues to grow as this week he (surprisingly?) endorsed a German conservative party that looks like MAGA on steroids," Karem wrote. "How is it that an immigrant from South Africa who is afforded all the freedoms of the world’s greatest nation would try to undermine the nation that allowed him to succeed beyond his wildest dreams? He doesn’t care. He wants it all and he wants it now. The man who bought and sold the world looks to be on Santa’s naughty list — so I doubt things in the new year will play out the way Husky Musky dreams. After all, his dream is a nightmare to millions of people worldwide." "I certainly find it funny that man who could easily dip into his pocket and donate $100 billion to ease student loan debt and help solve homelessness in this country — and still be worth hundreds of billions of dollars — is trying so hard to fit into a high school cheerleading outfit (complete with pom poms) for Donald Trump," Karem added. "It would be justice if Musk got a sequin-lined cheerleading outfit for Christmas — complete with autographed copies of Vance’s 'Hillbilly Elegy.'"WHITE SULPHUR SPRINGS, W.Va. (AP) — Jaland Lowe scored 19 of his career-high 22 points in the second half and collected eight rebounds and six assists in leading Pittsburgh to a 74-63 win over LSU at the Greenbrier Tip-Off on Friday. Pitt (6-0) will play the Wisconsin-UCF winner on Sunday for the tournament title. The Tigers (4-1) will take on the loser. This is Pitt's best start since 2018-19. Lowe made four 3-pointers while Ishmael Leggett added 21 points, six rebounds and five steals. Cameron Corhen scored 14 points and Zack Austin 10. The Panthers shot 64% in the second half after a 31% showing in the first. Jalen Reed had 14 points and seven rebounds, Vyctorius Miller came off the bench to score 14 points and Cam Carter added 11 for the Tigers, who shot 37%. LSU, which had trailed by as many as 12 in the second half, got within four on a four-point play by Miller with six minutes left but Lowe scored eight points, found Corhen for a pair of dunks and Leggett added seven points to help the Panthers pull away. Pitt stumbled at the end of the first half in surrendering the lead but came out in the second hot, hitting its first five shots and scoring the first 13 points. The Tigers missed their first 12 shots before finally getting a bucket and their first points from Carter nearly seven minutes into the second half. LSU had its only lead after Lowe was called for a technical foul with 4.9 seconds remaining in the first half and Carter hit a free throw to finish an 8-2 run to send the Tigers into the break ahead 28-27. ___ Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college basketball: https://apnews.com/hub/ap-top-25-college-basketball-poll and https://apnews.com/hub/college-basketball